Comparing your treatment options
IV ketamine, Spravato® esketamine, and standard oral medication each work differently. Here is an honest, side-by-side look — so the decision you make is an informed one.
- IV infusion
- Spravato esketamine
- Oral medication
| IV ketamine | Spravato® | Oral meds | |
|---|---|---|---|
| Regulatory status | Off-label (FDA-approved as an anesthetic) | FDA-approved for specific adult indications | FDA-approved |
| How it is given | IV infusion, ~40–60 min | Nasal spray, self-administered on-site | Daily pill at home |
| Where | In-clinic, supervised | Certified setting, supervised (REMS) | At home |
| Typical onset | Hours to days | Days to weeks | Weeks |
| Monitoring | Continuous during infusion | At least 2 hours after each dose | Routine follow-up |
| Dosing control | Highest — titrated in real time | Fixed device doses | Fixed tablet doses |
| Insurance | Often out-of-pocket | More often covered | Usually covered |
This overview is educational and generalized; the right option depends on your diagnosis, history, and coverage, and is decided with a qualified clinician.
IV ketamine
Often chosen when precise dose control matters, for chronic pain, or when the deepest research base is the priority.
About IV ketamineSpravato
Often chosen when FDA approval and insurance coverage are important, alongside an oral antidepressant.
About SpravatoStill deciding
You don't have to choose alone. A free consultation weighs your history and coverage and gives you a clear recommendation.
Check my coverageLet us help you weigh the options
Tell us your situation and a clinician will talk you through which route fits best — free, confidential, no obligation.